Berberine improves hepatic insulin resistance
Berberine is an isoquinoline alkaloid that is found in many medicinal plants and displays many pharmacological effects including anti-viral activity. Chinese Traditional Medicine has a long history of applying berberine to treat various infectious diseases. There are many researches and studies on this natural compound for its benefits to various metabolic diseases including diabetes. It shows that berberine improves diabetes, but what is the mechanism?
Hepatic insulin resistance is one of the major initiating factors for type 2 diabetes mellitus. In a previous study, berberine could enhance hepatic insulin sensitivity by SIRT1-dependent deacetylation of FOXO1. Can berberine improve hepatic insulin sensitivity by SIRT1/FOXO1 pathway? A study was introduced by the Endocrine and Diabetes Center, Department of Endocrinology of the Nanjing University of Chinese Medicine gave us more details about it. They tried to evaluate the efficacy of berberine for improving hepatic insulin resistance and the possible molecular mechanisms involved.
The in vivo and in vitro results of the study showed that berberine significantly improved glycogen synthesis in the liver in the condition of IR. The present findings and this study suggest that berberine could attenuate hepatic insulin resistance through the miR-146b/SIRT1 pathway, which may represent a potential therapeutic target for the prevention and treatment of metabolic diseases, particularly diabetes.
Reference:
https://www.dovepress.com/berberine-ameliorates-hepatic-insulin-resistance-by-regulating-microrn-peer-reviewed-fulltext-article-DMSO
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