6 approved Andrographis Paniculata benefits

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🍀What is Andrographis Paniculata?

Andrographis Paniculata benefits both human and animals, but what is Andrographis Paniculata(Andrographis)?  Andrographis is an annual herbal plant in the family Acanthaceae, it is an erect, branched herb that prefers shady, moist locations. Andrographis grows to a height of one to three feet (30-90 cm) and produces small, pink, or white flowers with brown or purple spots. Andrographis paniculata is a bitter-taste, therapeutic herb native to South Asian countries: India and Sri Lanka, it is an herb medicine long used in traditional Chinese medicine and  Ayurveda, most widely used to help manage cold and flu symptoms including upper respiratory Tract infections.

Andrographis is commonly known as creat, green chiretta, or India Echinacea, further, there are other vernacular names of Andrographis herb, parts of them are as follows:

Language

Name

Language

Name

Chinese

Chuanxinlian

Russian

Androgafis

English

King of bitters

Thai

Fa Talai Jone

Spanish

Androgafis

Malay

Hempedu Bumi

Japanese

Senshiren

Bengali

Kalmegh

Scandinavian

Green Chiretta

French

Chirette verte

Why Andrographis benefits us? The reason is the rich in bioactive compounds of its nature.But which bioactive constituents does Androgaphis herb contains? The main known chemical components of A. Paniculata are diterpene lactones, collectively referred to as andrographolides, which include aglycones (e.g., andrographolide; shown to be responsible for much of the herb’s anti-inflammatory activity), and glucosides (e.g., neoandrographolide and andrographolide), diterpene dimers, and flavonoids, as well as xanthone in the roots. And Andrographolide is the critical compound that makes the Andrographis herb taste bitter, that’s why it is named after the king of bitters.

🌴Where does the Andrographis plant grow in the world? 

Andrographis paniculata grows in south Asian countries such as India and Sri Lanka. However, it has been introduced to other Asian countries. Andrographis now grows in the islands of the Caribbean and West Indian Ocean, China (specifically Guangdong, Guangxi, Fujian, Yunnan, Sichuan, Jiangsu, and Jiangxi provinces), Indonesia, Laos, Malaysia, Myanmar, Thailand, Vietnam, and Mesoamerica. In China, the Chuanxinlian is cultivated mainly in Guangdong and Guanxi provinces, with a yield of 10,000 tons of dried Andrographis Paniculata herbs yearly. Andrographis grows in Zhanjiang, Guangdong province steps into harvest season earlier than that grow in Guangxi Province, as the weather becomes warm earlier than that of Guangxi, which resulted in earlier seeding.

🍀What are Andrographis Paniculata Benefits for you?

Why is Andrographis good for you? Andrographis plant has many health benefits. It has been used for centuries in China and India as a traditional herbal medicine for a range of ailments. Most importantly, many Andrographis Products are proved to be effective by modern clinically test RCTs(tested in parallel-group randomized, double-blind, placebo-controlled trials (RCTs) ). In short, it’s a multifaceted plant that can be added to your natural remedy medicine cabinet. This cold-property medicinal herb helps human:

🌴 1.Andrographis fights for the common cold and flu, shortens the duration of cold symptoms. 

According to a double-blind, placebo-controlled clinical study in 2010. 223 patients were randomized to receive either 200 mg/day K (an Andrographis Paniculata standardized extract with 30%+ andrographolide content) or a placebo for five days. 39 K was found to be 52.7% more effective than placebo. The K group experienced significantly reduced symptoms — including cough, expectoration, nasal discharge, headache, fever, sore throat, malaise/fatigue, and sleep disturbance. Evidence from 33 RCTs also suggested that A. Paniculata (alone or plus usual care) shortened the duration of cough, sore throat, and sick leave/time to resolution when compared versus usual care. Side effects were minor with no significant difference between groups. In one comparative clinical study, Andrographis was even more effective for children than echinacea – another herb used for treating colds. Not only that, but research also found that it was a safe and effective cold remedy for children.

Natural ingredients-Andrographis extract powders

🌴 2. Andrographis and Andrographis extract effectively treat mild-to-moderate ulcerative colitis.

Two clinical studies have evaluated the efficacy of Andrographis Paniculata extract HMPL-004 in treating mild-to-moderate ulcerative colitis in different years, both are randomized, double-blind. One is comparative, parallel-group research: HMPL-004 at dose 1200mg/day between 4500mg/day mesalazine. In this study, at this dose, HMPL-004 was determined to be similar to mesalazine in efficacy, and adverse events were rare and limited to allergic reactions (urticaria/hives). The other study, in 2013, was a placebo-controlled trial wherein patients with diagnosed ulcerative colitis (n=224), most of whom were failing first-line therapy with mesalazine, were randomized to receive either 1200 or 1800 mg daily HMPL-004 in three divided doses, or placebo for 8 weeks. This study concludes that the treatment with HMPL-004 was more effective than placebo in mucosal healing of mild-to-moderate active ulcerative colitis

🌴 3.The Andrographis benefit in treating upper respiratory infections (URI).

Much strong clinical evidence has investigated A. Paniculata’s effectiveness in treating URI, alone or in a combination product. A systematic review and meta-analysis included 33 RCTs(7175 patients) concludes that A. Paniculata improved cough (n = 596, standardised mean difference SMD: -0.39, 95% confidence interval CI [-0.67, -0.10]) and sore throat (n = 314, SMD: -1.13, 95% CI [-1.37, -0.89]) when compared with placebo. A. Paniculata (alone or plus usual care) has a statistically significant effect in improving overall symptoms of ARTIs when compared to placebo, usual care, and other herbal therapies. At least four additional studies between 1995 and 2002 evaluated 1200 mg daily Kan Jang(available with Andrographis extract (60 mg) alone and in combination with Eleutherococcus Senticosus extract (120 mg) for URI, It has been shown to reduce both the severity and duration of symptoms in URI’s. Treatment needs to be started within 48 hrs of symptom onset, and improvement can be seen as early as 2 days later. Further, studies have found it helped reduce inflammation in the pharynx and tonsils with one study finding it reduced inflammation in the tonsils and pharynx just as well as Tylenol. To sum up, these medicinal studies found statistically significant results in Andrographis treating URIs and ARTIs.

andrographis extract powder capsules

🌴 4.Andrographis for Coronavirus.

Coronavirus (covid-19), a world emergency disease, caused global concern, an approach in silico demonstrated Andrographolide as a potential inhibitor of covid-19 main protease in April 2020.

As herb Andrographis, green chiretta (Andrographis paniculate) – or Fah Talai Jone, as it’s called in Thailand, is an inexpensive and effective traditional herbal medicine commonly used in Thai homes to treat colds, Thai researchers chose it for more researches and studies after screened 122 Thai natural products for activity against the virus that causes COVID-19. Among six selected candidates, purified compound andrographolide from Andrographis extract exhibited 99.9% inhibitory activity against the virus in cell cultures. Andrographis is now playing a central role in the country’s fight against COVID-19 after a series of researches in Thailand.

Phase 1 of the Thai research initiative on Andrographis started in late June 2020 at two hospitals. There, 12 patients received either 60 mg or 100 mg capsules of the extract, three times per day if they were confirmed to be infected with COVID-19 and had mild to moderate symptoms for no more than 72 hours. Results showed that the lower dose showed benefits, especially for coughing. Within three days, cough volume and overall symptom severity decreased significantly. After five days, other symptoms improved, and real-time polymerase chain reaction (PCR) tests were negative for the COVID-19 virus in two patients. After three weeks, real-time PCR tests were negative in all six subjects.

The phase 2 study was disturbed by the hit of second waves, and they directly approved the pilot study with Andrographis remedy to treat early symptoms of COVID-19 and reduce the severity of the virus at the end of 2020, in an emergency. The pilot study is satisfied as patients receiving Andrographis paniculata in doses with andrographolide 180mg/day of 309 found that only 3 cases needed a treat, that is,0.97% needed treat. On the other hand, in the placebo group who did not receive andrographolide dose treatment,77 of 526 patients got worse with more severe symptoms, such as pneumonia and intubation. Further, the trial on prison inmates also supports the Andrographis remedy in Thailand. In the trial 11,800 infected prison inmates with mild symptoms and 99.02% of them recovered, which showed Andrographis can prevent the virus from entering cells while reducing viral replication. Therefore, Thailand’s cabinet approved green chiretta for use in people with asymptomatic or mild coronavirus infections In July 2021.

🌴 5.Andrographis relieves rheumatoid arthritis (RA).

An Andrographis leaf extract has been evaluated for its role in the relief of RA. In 2009, a prospective, randomized, double-blind, placebo-controlled study investigated the efficacy of 30 mg Andrographis extract 30% andrographolides three times per day for 14 weeks. 46 Sixty women were randomized into two groups, one receiving Andrographis, and the other receiving placebo. The Andrographis group experienced a significant reduction in tender joints, number of swollen joints, and total grade of tender joints.

🌴6.Skin health

Studies have found that topical applications made with the herb can help improve skin elasticity as well as suppress wrinkles and thickening of the skin caused by UV rays. And there is andrographis ingredient approved for use in cosmetic products by the European Commission Health and Consumers Directorate General: “Andrographis Paniculata Leaf Extract,” which is listed as an astringent and skin-conditioning substance

Andrographolide structure.Andrographolide99-purifed Andrographis extract

🍀Current authorized Andrographis uses and who monographs?

We realized the benifits of Andrographis Paniculata and there are researches & clinical studies here before, meanwhile, there are many monographs about it, and many Andrographis supplements and Andrographis medicine. Chinese pharmacopeia lists standards for the herb and herbal extract and there are at least 25 formulas for human beings, except the animal healthcare ones. Similarly, Andrographis paniculata finds its reference in 26 Ayurvedic formulations in India. English-language Andrographis Paniculata monographs have been published in the WHO Monographs on Selected Medicinal Plants and in the United States Pharmacopia. Herba Andrographis is classified as a medicinal ingredient in Canada where it is listed in Table 1 of the Natural Health Product(NHP) Traditional Chinese Medicinal Ingredients monograph.

🍀Is Andrographis Paniculata Safe? (Possible Side Effect)

Andrographis is considered to be safe, but the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established. So Andrographis is not recommended during pregnancy or while breastfeeding. If you have an autoimmune disease, consult a physician before using Andrographis, as it is a stimulant that works to stimulate the immune system. And people with bleeding disorders or low blood pressure should not use the herb or its compounds without consulting with their health care providers. It’s also recommended to avoid using the plant if you are on medications for slowing blot clots, including aspirin, ibuprofen, and warfarin.

🍀Conclusion

Andrographis is an herb plant with thousands of years of use history in traditional and folk medicine. It seems to make your health from inside out as It is applied for a range of health conditions and skincare, including respiratory tract infections, fever, digestion, recognition, and inflammatory conditions. Andrographis is available in tea, powders, capsule, tincture, and extract forms.

Reference:

1.Hovhannisyan AS, Abrahamyan H, Gabrielyan ES, Panossian AG. The effect of Kan Jang extracts on the pharmacokinetics and pharmacodynamics of warfarin in rats. Phytomedicine. 2006;13(5):318-323.

2.American Botanical Council :Mariann Garner-Pharmacology and clinical effects of Andrographis

3.Can Andrographis boost immune function.

4.https://draxe.com/nutrition/andrographis/

5.Chien CF, Wu YT, Lee WC, Lin LC, Tsai TH. Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chem Biol Interact. 2010;184(3):458-465.

6.https://healthyfocus.org/health-benefits-of-andrographis/

7.Hu X-Y, Wu R-H, Logue M, Blondel C, Yuen Wan Lai L, Stuart B, Flower A, Fei Y-T, Moore M, Shepherd J, Liu J-P, Lewith G. Andrographis paniculata (Chuan Xin Lian) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis, PlosOne, 2017; 12(8):e0181780.

8.A Puri1R SaxenaR P SaxenaK C SaxenaV SrivastavaJ S Tandon Immunostimulant agents from Andrographis paniculata J Nat Prod 1993 Jul;56(7):995-9.doi: 10.1021/np50097a002.

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