Natural product-intermediate-10hydroxycamptothecin

10-Hydroxycamptothecin(HCPT), same as camptothecin, is a phytochemical constituent from the Camptotheca Acuminate tree(happy tree), native in China. The other nature-based way to get 10-Hydroxycamptotheicn is hydroxylating the natural camptothecin, originated from Mappia roots. This natural compound belongs to the class of organic compounds known as camptothecins. These are heterocyclic compounds comprising a planar pentacyclic ring structure, that includes a pyrrolo[3,4-beta]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D), and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring).

As a basic common anticancer drug produced by several pharmaceutical companies, HCPT has been used clinically for different cancer patients mainly with gastrointestinal carcinoma, tumors of the head and neck with marked therapeutic effects.

Benenature keeps a sustainable supply of naturally sourced camptothecin and 10-Hydroxycamptothecin. We repurpose our biomass as fertilizer and recycle the extraction solvent with our unique recycling system.

Benenature strictly controls the single impurity of HCPT, single impurity is as low as 0.5% by HPLC. We also offer a service of customized single impurity, to make it much easier for your research and synthesis of SN-38.