Natural product-intermediate-10hydroxycamptothecin


Benenature code: BNO13
Botanical source: Nothapodytes Pittosporoides(Mappia) (Camptothecin)

Used part: stems and roots
Test Method: HPLC
Appearance: Light yellow crystal powder.

10-Hydroxycamptothecin(HCPT), same as camptothecin, is a phytochemical constituent from the Camptotheca Acuminate tree(happy tree), native in China. The other nature-based way to get 10-Hydroxycamptotheicn is hydroxylating the natural camptothecin, originated from Mappia roots. This natural compound belongs to the class of organic compounds known as camptothecins. These are heterocyclic compounds comprising a planar pentacyclic ring structure, that includes a pyrrolo[3,4-beta]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D), and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring).

As a basic common anticancer drug produced by several pharmaceutical companies, HCPT has been used clinically for different cancer patients mainly with gastrointestinal carcinoma, tumors of the head and neck with marked therapeutic effects.

Benenature keeps a sustainable supply of naturally sourced camptothecin and 10-Hydroxycamptothecin. We repurpose our biomass as fertilizer and recycle the extraction solvent with our unique recycling system.

Benenature strictly controls the single impurity of HCPT, single impurity is as low as 0.5% by HPLC. We also offer a service of customized single impurity, to make it much easier for your research and synthesis of SN-38.

Testing lab to control the quality of plant extracts and natural ingredients.
10-Hydroxycamptothecin single impurity<0.5% by HPLC.
roots of mappia
Sustainable origin of raw materials for camptothecin extraction.
Alcohol recycled tech applied for andrographolide and other plant extracts..
Bulk 10-hydroxycamptothecin supplies.
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Characteristic of Benenature 10-Hydroxycamptothecin

🌿100% Natural Camptothecin orginated.

🌿Single impurities strictly controlled: single impurity<0.5%.

🌿Purity of HCPT>99.00%, a choice to be a reference substance

🌿Always in stock with bulk quantities.

Chemical Information of 10-Hydroxycamptothecin

Chemical Structure:


Chemical Formula: C20H16N2O5


🍀Topoisomerase inhibitor for anticancer.


🍀HCPT is key raw material for SN-38 semi-synthesis.
🍀Key raw material for Irinotecan Hydrochloride synthesis.
🍀Active Intermediate for synthesis of Topotecan.


10-Hydroxycamptothecin is generally packed in two food-grade plastic bags with IATA required carton, net Weight:5.0kg/carton. At the same time, 1kg or 500g aluminum foil bag is available for your unique needs, Net Weight:5.0kg/IATA carton.Please store HCPT in a cool and dry place, avoid direct sunlight.


Three years when sealed and properly stored.

Shelf Life

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10+ years focusing on plant extracts manufacturing.

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Order lead time less than 7days, OEM/OEM samples can be ready for shipping within 7 days.

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Benenature is your solid plant extracts manufacturer and botanical ingredients solution provider.