7-Ethyl-10-Hydroxycamptothecin(SN-38) is a semisynthetic analog of camptothecin in which the hydroxyl group at the C10 position and the ethyl group at the C7 position help to stabilize SN38 in physiological environments. Benenature’s SN38 route is as follows:

Mappia roots👉camptothecin👉10-Hydroxycamtpothecin👉SN38.

(SN-38) is a topoisomerase I inhibitor for anti-cancer therapy, the biologically active metabolite of Irinotecan HCl(CPT-11). SN-38 causes the strongest inhibition of DNA topoisomerase I, followed by CPT and then CPT-11.

Benenature keeps a sustainable supply of naturally sourced camptothecin and camptothecin derivatives including SN38. We recycle the extraction solvent with our unique recycling system.